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Research supervisor: 
Sergey Leonov
MD PhD
 
Supervisor’s research interests:
  •  DNA repair and Aging.
  •  Mechanobiology of Cancer cells.
  •  Extracellular vesicles and cancer dissemination.
  •  New biomarkers of cancer invasiveness and radio resistance.
  •  Pharmacological modulation of EMT, stemness and radio resistance.
  •  Natural products for microbiology, oncology and aging. 

Research highlights:
  •  High Content Imaging & Analysis Platform.
  •  Development a novel technology for the early detection of triple negative breast cancer.
  •  High Throughput Target Identification and Validation Platform for Drug Discovery.
  •  Joint projects in Oncology (Prof. Alexis GAUTREAU, CNRS, France), Biotechnology of natural compounds (UNERA Luxembourg S.A) and System Biology (Prof. Jens Schwamborn, The University of Luxembourg and  Prof. Hans V. Westerhoff, VU University Amsterdam).
  •  In vivo aging and neurodegeneration model on Caenorhabditis elegans.


Supervisor’s specific requirements:
  •  MS in Biology and/or Biotechnology or related disciplines.
  •  Hands-on experience with basic biochemical & biophysical and molecular biology methods.
  •  Proficient in the use of Microsoft Office packages.
  •  Problem-solving skills, ability to work under time pressure and get results.
  •  Desirable: knowledge and motivated interest in above mentioned research of our Lab. 


Main publications:
  •  Brel VK, Artyushin OI, Chuprov-Netochin RN, Leonov SV, et al.  Synthesis and biological evaluation of indolylglyoxylamide bisphosphonates, antimitotic microtubule-targeting derivatives of indibulin with improved aqueous solubility. Bioorganic & Medicinal Chemistry Letters 2020;30(23), 127635. https://doi.org/10.1016/j.bmcl.2020.127635
  •  Marusich E, Mohamed H, Afanasev Y, Leonov S. Fatty Acids from Hermetia illucens Larvae Fat Inhibit the Proliferation and Growth of Actual Phytopathogens. Microorganisms 2020; 8, 1423. https://doi.org/10.3390/microorganisms8091423
  •  Pustovalova M, Alhaddad L, Smetanina N, Chigasova A, Blokhina T, Chuprov-Netochin R, et al. The p53-53BP1-Related Survival of A549 and H1299 Human Lung Cancer Cells after Multifractionated Radiotherapy Demonstrated Different Response to Additional Acute X-ray Exposure. Int J Mol Sci 2020;21. https://doi.org/10.3390/ijms21093342
  •  Ustyantseva EI, Medvedev SP, Vetchinova AS, Illarioshkin SN, Leonov SV, Zakian SM. Generation of an induced pluripotent stem cell line, ICGi014-A, by reprogramming peripheral blood mononuclear cells from a patient with homozygous D90A mutation in SOD1 causing Amyotrophic lateral sclerosis. Stem Cell Research 2020;42:101675. https://doi.org/10.1016/j.scr.2019.101675
  •  Ulyanenko S, Pustovalova M, Koryakin S, Beketov E, Lychagin A, Ulyanenko L, et al. Formation of γH2AX and pATM Foci in Human Mesenchymal Stem Cells Exposed to Low Dose-Rate Gamma-Radiation. International Journal of Molecular Sciences 2019;20:2645. https://doi.org/10.3390/ijms20112645
  •  Anumala UR, Waaler J, Nkizinkiko Y, Ignatev A, Lazarow K, Lindemann P, et al. Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. J Med Chem 2017;60:10013-25. https://doi.org/10.1021/acs.jmedchem.7b00883

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